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Jan 16,  · Clarithromycin: Drug-Drug Interactions. Antifungal imidazoles. In three patients with pulmonary MAC and aspergillosis infections, itraconazole was suggested to increase the plasma concentration of clarithromycin as well as the clarithromycinhydroxyclarithromycin ratio. This effect may have been due to inhibition of CYP3A4 by itraconazole.

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